Tissue Engineered Models of Brain Tumors and Their Applications

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FIGURE 3.1

Selected examples of soluble molecules and membrane-associated proteins in

invasive, immunosuppressive and angiogenic networks of immune system cells

and tumors. BLACK arrows mark the activation of target cells with rele-

vant factors. BLUNT BLACK arrows point out inhibitory activity through

the mentioned factors. GREY arrows indicate factors involved in angiogene-

sis. DASHED arrows represent immune activity against the tumor. DASHED

GREY arrows show factors in direct effect on tumor cells to promote invasion.

The figure was generated using Servier Medical Art, provided by Servier, li-

censed under a Creative Commons Attribution 4.0 unported license.